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Proskurnin M. A., Orlova N. V., Pikhtar' A. V., Kuznetsova V. V.

Determination of p-Aminophenol in Paracetamol by Reaction with Resorcinol Using Thermal Lens Spectrometry

Abstract

The conditions for photometric determination of p-aminophenol by its reaction with resorcinol in alkaline solutions were found. The limit of detection is 2 mg/mL. Thermal lensing under these conditions provided the limit of detection of 0.1 mg/mL; thus, a 20-fold increase in the sensitivity was attained. The achieved limit of detection is fivefold lower than the value for the standard procedure for the determination of p-aminophenol with sodium nitroprusside. The procedure was verified by determining p-aminophenol in samples of paracetamol produced by several pharmaceutical companies.
Moscow University Chemistry Bulletin.
2001, Vol. 42, No. 1, P. 30
   

Copyright (C) Chemistry Dept., Moscow State University, 2002
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