ChemNet
 
Previous article Next article Contents  

Gurevich K. G.

Mathematical modeling application for receptor binding parameter estimation

Abstract

Mathematical modeling was used for receptor binding parameter estimation in systems, in which analysis with traditional methods (Scatchard, Hill, Bierrum anaysis and so on) is much difficult or impossible: cooperative binding, presence of several binding sites, nonequilibrium binding. Using literature it was analyzed 23 receptor systems with different chemical nature of endogenous and exogenous ligands. It was shown that conjugate gradients method allow to find binding parameters in all cases, in which analysis with traditional methods is impossible or much difficult. Parameters which were received using mathematical modeling allow to approximate experimental data then such parameters which were received using traditional methods. It may be suggested that mathematical modeling may be also useful for analysis of such systems as ‘enzyme-substratum’, ‘blood protein-hormone’, ‘antigen-antibody’.
Moscow University Chemistry Bulletin.
2001, Vol. 42, No. 1, P. 54
   

Copyright (C) Chemistry Dept., Moscow State University, 2002
   Overview
   Editorial board
   Tables of Contents
   Subscription

The site is supported by Russian Foundation for Basic Research
  The using of published on this page materials is not allowed without special permission
Copyright (C) Chemisty Department of Moscow State University
Web-Editor: B.I.Pokrovskii
Web-design: Copyright (C) MIG and VVM
webmaster@www.chem.msu.su