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Yeremeyev N. L., Kurochkin I. N., Yeriomenko A. V., Varfolomeyev S. D., Rainina Ye. N.

Selection of Conditions for Enzyme Inhibitor Analysis: Theoretical Consideration

Abstract

Theoretical consideration of mechanisms of inhibitors interactions with enzymes was done from the point of view of enzyme inhibitor analysis requirements. It was shown that the knowledge of inhibition mechanism permits to develop true strategy of analytical procedure conducting with the presentation of experimental data in the form of comfortable linear calibrating dependencies. Detection limits for each considered variant of analysis were calculated. Factors affecting the procedure of irreversible inhibitors determination were discussed.
Moscow University Chemistry Bulletin.
2002, Vol. 43, No. 6, P. 412
   

Copyright (C) Chemistry Dept., Moscow State University, 2002
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