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A. N. Korovina, M. V. Yasco, A. V. Ivanov, A. L. Khandazhinskaya, E. V. Karamov, G. V. Kornilayeva, M. K. Kukhanova

New HSV and HIV replication inhibitors on the base of phosphonate nucleoside analogs

Abstract

Two types of nucleoside analogs were synthesized: acyclic Z- and E-isomers of 9-[3-(phosphonomethoxy)prop-1-en-1-yl]adenine and carbocyclic isosteric analog of guanosine monophosphate. Acyclic (Z)- and (E)- isomers suppressed HSV and HIV replication and were not toxic for eukaryotic cells. The activity of (Z)- isomer against both viruses was higher than that of (E)- isomer. Diphosphates of these compounds demonstrated high substrate activity towards the recombinant HSV DNA polymerase and HIV reverse transcriptase. The diphosphatephosphonate of the carbocyclic guanosine analog didn’t display notable substrate activity towards HSV DNA polymerase but acted as a substrate of HIV RT.
Moscow University Chemistry Bulletin.
2008, Vol. 49, No. 2, P. 108
   

Copyright (C) Chemistry Dept., Moscow State University, 2002
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