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A. M. Banaru

Conformation of 1,4-dihydropyridine calcium channel blockers and H-bonds in the crystal

Abstract

On the basis of data accumulated in Cambridge Structural Database a statistical analysis of conformations for flexible 1,4-dihydropyridine calcium channel blockers, the derivatives of nifedipine, was performed. Confirmed was the inequality of N and C deviations from the mean plane of heterocycle. The correlation between carbonyls orientation and the ability to form H-bonds in a crystal was established.
Moscow University Chemistry Bulletin.
2008, Vol. 49, No. 6, P. 385
   

Copyright (C) Chemistry Dept., Moscow State University, 2002
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