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T. V. Sukhanova, I. A. Prudchenko, E. S. Efremov, S. V. Uglanova, L. Yu. Filatova, E. A. Markvicheva, N. L. Klyachko

Biomolecules in colloid nanocarriers for drug delivery: entrappment and properties of delta-sleep inducing peptide

Abstract

Nanoemulsions of water in oil type using non-toxic components on the base of AOT (5%) and soya bean lecithin Lipoid S100 (10%) in eucalyptus oil and limonene were developed and characterized. As shown, AOT based systems possessed maximal solubilization capacity (12% of aqueous solution); sizes measured with photon-correlation spectroscopy were in linear dependence with water content. As shown, hydrophilic delta-sleep inducing peptide (DSIP) (regulatory neuropeptide) was able to be included into nanoemulsions of w/o type in the absence and presence of biopolymeric additives. DSIP entrapment into nanoemulsion led to its significant stabilization (80–90% after 2 months of incubation at 22oC in contrast to 28% in water). Peptide release kinetics was studied in model in vitro experiment (dialysis) and significant retardation of DSIP release from nanoemulsion in comparison with water was found. DSIP containing nanoemulsion systems useful for medicine and cosmetics can serve as a base for development of novel stable drug formulations of durable action.
Moscow University Chemistry Bulletin.
2010, Vol. 51, No. 3, P. 209
   

Copyright (C) Chemistry Dept., Moscow State University, 2002
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