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N. M. Zadymova, N. I. Ivanova
Simultaneous solubilization of lipophilic
drug, amlodipine, and glyceryl monolaurate in aqueous micellar solutions of Tween 80
Abstract
Solubilization and co-solubilization of
lipophilic amlodipine (Am – antihypertensive drug) and glyceryl monolaurate
(GML – enhancer of the skin permeability) in micelles of Tween 80 (Tw) in water
medium were studied using UV-spectroscopy and refractometry. Such properties of
the mixed micelles (Tw + GML, Tw + Am, Tw + GML + Am) as aggregation numbers of
components, locus of solubilizates, diffusion coefficients, sizes, and
hydration were investigated. The ternary micelle (Tw + GML + Am) includes in
4,2-times more molecules of drug than the two-component one. It was shown that
the diffusion of mixed micelles (Tw + Am, Tw + GML + Am) defines the mass
transfer of Am in aqueous solutions.
Key words: micelles of surfactant,
solubilization, co-solubilization of drug and enhancer of the skin
permeability, amlodipine, glyceryl monolaurate, Tween 80.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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