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I. S. Panina, L. Y. Filatova, A. V. Kabanov, N. L. Klyachko

Investigation of physicochemical properties of both glutathione eroxidase I and its complexes with polyelectrolytes as promising agents for the treatment of central nervous system diseases

Abstract

A study of kinetics of thermal inactivation of glutathione peroxidase I was carried out. Glutathione peroxidase is an enzyme that plays a key role in the antioxidant protection system of the body. It was shown that oligomeric glutathione peroxidase I is inactivated by monomolecular mechanism (37ºC, pH 7.0, the enzyme concentrations of 0.3 and 1 mg/ml). An effective way to stabilize the enzyme by polyelectrolytes of different nature was proposed.
Key words: active forms of oxygen, glutathione peroxidase I, polyelectrolyte, kinetic of inactivation, stabilization.
Moscow University Chemistry Bulletin.
2014, Vol. 55, No. 3, P. 153
   

Copyright (C) Chemistry Dept., Moscow State University, 2002
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