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P. A. Levashov, D. A. Matolygina, H. E. Osipova, S. S. Savin, G. S. Zaharova, D. A. Gasanova, N. G. Belogurova, E. D. Ovchinnikova, S. A. Smirnov, V. I. Tishkov, A. V. Levashov

Comparison of bacteriolytic activity of human interleukin-2 and chicken egg lysozyme on the cells of Lactobacillus plantarum and Escherichia coli

Abstract

This paper continues the study of the recently discovered bacteriolytic activity of interleukin-2. It has earlier been revealed that interleukin-2 (IL-2) has a narrower substrate specificity in comparison with chicken egg lysozyme. IL-2 destroys Escherichia coli, but can not destroy Micrococcus luteus and Bacillus subtilis. For the first time in the present study it is demonstrated that IL-2 is capable to destroy Lactobacillus plantarum. The action of IL-2 and that of chicken egg lysozyme are compared in their effect on Lactobacillus plantarumand Escherichia coli. There have been investigated the dependences of the rate of lysis on the concentration of bacteriolytic factors, pH and ionic strength.
Key words: interleukin-2, chicken egg lysozyme, Lactobacillus plantarum, Escherichia coli, bacteriolytic activity.
Moscow University Chemistry Bulletin.
2015, Vol. 56, No. 6, P. 359
   

Copyright (C) Chemistry Dept., Moscow State University, 2002
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