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E. A. Kirzhanova, M. A. Pechenkin, N. B. Demina, N. G. Balabushevich

Alginate/chitosan micro- and nanoparticles for protein mucosal delivery

Abstract

Layer-by-layer adsorption and ionotropic gelation methods were used for insulin, aprotinin and interferon entrapment to alginate/chitosan matrices. Protein encapsulation efficacy, particles size and ζ-potential, mucin binding and protein release in physiological conditions were studied and discussed with regard to their further possible mucoadhesive administration.
Key words: alginate, chitosan, protein encapsulation, ionotropic galation, layer-by-layer adsorption, mucoadhesive drug delivery systems.
Moscow University Chemistry Bulletin.
2016, Vol. 57, No. 2, P. 103
   

Copyright (C) Chemistry Dept., Moscow State University, 2002
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